Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970453 | 0.88 | L3MBTL1 (0.38) | ELOVL1IDO1TDO2IDO2KDM4E | |
| SCHEMBL3958654 | 0.87 | MAPT (0.36) | HTTELOVL1IDO1TDO2IDO2 | |
| SCHEMBL3963734 | 0.87 | DRD2 (0.45) | MCHR1KCNH2ELOVL1IDO1TDO2 | |
| SCHEMBL3970359 | 0.86 | ELOVL1 (0.46) | KCNH2ELOVL1IDO1TDO2IDO2 | |
| SCHEMBL4198373 | 0.84 | KCNH2 (0.39) | MCHR1KCNH2ELOVL1 | |
| SCHEMBL3969490 | 0.84 | KCNH2 (0.41) | KCNH2KDM4EMAPTLMNASMO | |
| SCHEMBL3964828 | 0.83 | KCNH2 (0.43) | KCNH2TSHRELOVL1IDO1TDO2 | |
| SCHEMBL3962203 | 0.83 | ELOVL1 (0.39) | KCNH2ELOVL1IDO1TDO2IDO2 | |
| SCHEMBL3962968 | 0.82 | IDO1 (0.42) | ELOVL1IDO1TDO2IDO2KDM4E | |
| SCHEMBL3966727 | 0.82 | PIK3CD (0.40) | KCNH2TSHRELOVL1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | claimed |
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | disclosed |