Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964100 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2328633 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL27778358 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2328635 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL3965621 | 0.79 | KDM2B (0.66) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5318682 | 0.76 | KDM2B (0.49) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL4079510 | 0.73 | KDM2B (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3712025 | 0.73 | MGLL (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3711728 | 0.72 | STS (0.57) | MEN1KMT2A | |
| SCHEMBL4972870 | 0.72 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |