Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 8/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975598 | 0.81 | MEN1 (0.53) | KDM2BMEN1KMT2AALDH1A1MGLL | |
| SCHEMBL3965621 | 0.81 | KDM2B (0.66) | KDM2BMEN1KMT2AALDH1A1 | |
| SCHEMBL1857032 | 0.81 | MEN1 (0.50) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL2321941 | 0.81 | MEN1 (0.50) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL27778357 | 0.81 | KDM2B (0.40) | KDM2BTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL3968256 | 0.80 | ALDH1A1 (0.48) | KDM2BMEN1KMT2AALDH1A1MGLL | |
| SCHEMBL2145821 | 0.73 | HSD11B1 (0.53) | MEN1KMT2AALDH1A1MGLL | |
| SCHEMBL5318682 | 0.73 | KDM2B (0.49) | KDM2BMEN1KMT2AALDH1A1PDE2A | |
| SCHEMBL3966027 | 0.73 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1 | |
| SCHEMBL10132433 | 0.73 | ALDH1A1 (0.50) | TAS1R3TAS1R1TAS1R2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074108-A1 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2008036247-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |