Sugi Predict

Sugi Predict / Compounds / SCHEMBL396633

SCHEMBL396633

SCHEMBL396633

Nc1ccccc1-c1ccc(F)c(F)c1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ FEN1 P39748 9/20 0.55
▸ ALOX5AP P20292 5/20 0.55
▸ ALDH1A1 P00352 2/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ DHFR P00374 1/20 0.45
▸ MAOB P27338 1/20 0.42
▸ BACE1 P56817 1/20 0.41
▸ BRD4 O60885 1/20 0.41
▸ PDE3B Q13370 1/20 0.40
▸ PDE3A Q14432 1/20 0.40
▸ MAP4K4 O95819 1/20 0.39
▸ PTGS1 P23219 1/20 0.39
▸ PTGS2 P35354 1/20 0.39
▸ PTPRC P08575 1/20 0.39
▸ PTPN1 P18031 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29647556 1.00 FEN1 (0.55) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL3787019 0.88 ALDH1A1 (0.52) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL3781007 0.88 FEN1 (0.55) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL3904951 0.82 FEN1 (0.51) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL397260 0.82 PTGS2 (0.58) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL394650 0.82 ALOX5AP (0.48) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL31161110 0.82 PTGS2 (0.58) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL977502 0.81 ALDH1A1 (0.54) FEN1ALOX5APALDH1A1HSD17B10L3MBTL1
SCHEMBL13439490 0.80 PTPRC (0.57) FEN1ALOX5APALDH1A1L3MBTL1MAOB
SCHEMBL30665733 0.80 PTPRC (0.57) FEN1ALOX5APALDH1A1L3MBTL1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117903168-A Pyrrolo [2,3-d ] thiazole derivatives, and preparation method and application thereof 南开大学 2024-04-19 — — CN claimed
CN-116082163-B Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-10-13 — — CN claimed
CN-116082163-A Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-05-09 — — CN claimed
EP-3500551-B1 PROCESS FOR PREPARING SUBSTITUTED BIPHENYLS BASF SE (DE) 2021-11-10 — — EP claimed
US-10683256-B2 Process for preparing substituted biphenyls BASF SE (DE) 2020-06-16 — — US claimed
US-20190210954-A1 Process for Preparing Substituted Biphenyls LIANHE CHEMICAL TECHNOLOGY CO., LTD (CN) 2019-07-11 — — US claimed
EP-1252140-B1 PYRROLECARBOXAMIDES AND PYRROLETHIOAMIDES AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2009-05-13 — — EP claimed
CN-117903168-A Pyrrolo [2,3-d ] thiazole derivatives, and preparation method and application thereof 南开大学 2024-04-19 — — CN disclosed
CN-116082163-B Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-10-13 — — CN disclosed
CN-116082163-B Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-10-13 — — CN disclosed
CN-116082163-B Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-10-13 — — CN disclosed
CN-116082163-A Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-05-09 — — CN disclosed
CN-116082163-A Preparation method of 3',4' -difluoro-2 ' -aminobiphenyl 河北凡克新材料有限公司 2023-05-09 — — CN disclosed
US-20090246820-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH VERTEX PHARMACEUTICALS INCORPORATED 2009-10-01 — — US disclosed
US-20090227797-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-09-10 — — US disclosed
EP-2076602-A2 PLANT PRODUTIVITY ENHANCEMENT BY COMBINING CHEMICAL AGENTS WITH TRANSGENIC MODIFICATIONS BASF SE (DE) 2009-07-08 — — EP disclosed
US-7495103-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-02-24 — — US disclosed
WO-2008129060-A2 PLANT PRODUTIVITY ENHANCEMENT BY COMBINING CHEMICAL AGENTS WITH TRANSGENIC MODIFICATIONS BASF SE (DE) 2008-10-30 — — WO disclosed
US-20080071095-A1 Cystic fibrosis transmembrane conductance VERTEX PHARMACEUTICALS INCORPORATED (US) 2008-03-20 — — US disclosed
US-20060074075-A1 including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders VERTEX PHARMACEUTICALS INCORPORATED 2006-04-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10683256-B2 Process for preparing substituted biphenyls PIK3CA, PIK3CB, PIK3CG FEN1 2644/4885ALOX5AP 2067/4885ALDH1A1 3096/4885
US-20090227797-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 FEN1 2888/4885ALOX5AP 2982/4885ALDH1A1 2165/4885
US-20190210954-A1 Process for Preparing Substituted Biphenyls PIK3CA, PIK3CB, PIK3CG FEN1 2644/4885ALOX5AP 2067/4885ALDH1A1 3096/4885
US-20080071095-A1 Cystic fibrosis transmembrane conductance CFTR, ABCB1, ABCC1 FEN1 3740/4885ALOX5AP 3204/4885ALDH1A1 2651/4885
US-20060074075-A1 including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders CFTR, ABCC4, ABCC2 FEN1 3165/4885ALOX5AP 2896/4885ALDH1A1 2221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.