Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.58 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.48 |
| ▸ | FEN1 | P39748 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.46 |
| ▸ | FADS1 | O60427 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31161110 | 1.00 | PTGS2 (0.58) | PTGS2PTGS1ALOX5APFEN1ADORA2A | |
| SCHEMBL3904951 | 0.85 | FEN1 (0.51) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL3787019 | 0.82 | ALDH1A1 (0.52) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL20898128 | 0.82 | PTGS2 (0.58) | PTGS2PTGS1ADORA2AADORA1EPHB4 | |
| SCHEMBL31067152 | 0.82 | PTGS2 (0.58) | PTGS2PTGS1ADORA2AADORA1EPHB4 | |
| SCHEMBL331060 | 0.82 | AHR (0.54) | ADORA1ALDH1A1HSD17B10L3MBTL1DHFR | |
| SCHEMBL1300021 | 0.82 | ALDH1A1 (0.61) | PTGS2PTGS1ALOX5APFEN1ADORA2A | |
| SCHEMBL396633 | 0.82 | FEN1 (0.55) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL29647556 | 0.82 | FEN1 (0.55) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL29962162 | 0.82 | AHR (0.54) | ADORA1ALDH1A1HSD17B10L3MBTL1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3705477-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3216787-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | disclosed |
| US-20160318931-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-03 | — | — | US | disclosed |
| US-20150315186-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2015-11-05 | — | — | US | disclosed |
| US-20150293078-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | VERTEX PHARMACEUTICALS INCORPORATED | 2015-10-15 | — | — | US | disclosed |
| US-20150231142-A1 | Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases | VERTEX PHARMA (US) | 2015-08-20 | — | — | US | disclosed |
| US-20050124815-A1 | Difluoromethyl thiazolyl carboxanilides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
| US-20050119347-A1 | Microbicidal agents on the basis of biphenyl benzamide derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2005-06-02 | — | — | US | disclosed |
| EP-1501820-A1 | METHYLTHIOPHENE CARBOXANILIDES | Bayer CropScience AG (DE) | 2005-02-02 | — | — | EP | disclosed |
| EP-1480516-A1 | MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES | Bayer CropScience AG (DE) | 2004-12-01 | — | — | EP | disclosed |
| EP-1474407-A1 | DIFLUOROMETHYL THIAZOLYL CARBOXANILIDES | Bayer CropScience AG (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-1474406-A1 | DISUBSTITUTED THIAZOLYL CARBOXANILIDES AND THEIR USE AS MICROBICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003091240-A1 | METHYLTHIOPHENE CARBOXANILIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-11-06 | — | — | WO | disclosed |
| WO-2003069995-A1 | MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-08-28 | — | — | WO | disclosed |
| WO-2003066610-A1 | DIFLUOROMETHYL THIAZOLYL CARBOXANILIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-08-14 | — | — | WO | disclosed |
| WO-2003066609-A1 | DISUBSTITUTED THIAZOLYL CARBOXANILIDES AND THEIR USE AS MICROBICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | PTGS2 1409/4885PTGS1 1305/4885ALOX5AP 2982/4885 |
| US-20050119347-A1 | Microbicidal agents on the basis of biphenyl benzamide derivatives | DDT, MSR1, CYP1B1 | PTGS2 1834/4885PTGS1 2449/4885ALOX5AP 1144/4885 |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | PTGS2 1409/4885PTGS1 1305/4885ALOX5AP 2982/4885 |
| US-20150315186-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | PTGS2 1409/4885PTGS1 1305/4885ALOX5AP 2982/4885 |
| US-20050124815-A1 | Difluoromethyl thiazolyl carboxanilides | MRPL21, FOXM1, FLT3 | PTGS2 4056/4885PTGS1 3627/4885ALOX5AP 4365/4885 |
| US-20150231142-A1 | Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases | CFTR, SLC26A4, ABCB11 | PTGS2 1437/4885PTGS1 1130/4885ALOX5AP 2036/4885 |
| US-20160318931-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | PTGS2 1409/4885PTGS1 1305/4885ALOX5AP 2982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.