Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489951 | 0.73 | KDM4E (0.37) | KDM4EHTTKMT2ASMN1; SMN2PRKDC | |
| SCHEMBL11036457 | 0.67 | KEAP1 (0.40) | KDM4EHTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL40342 | 0.67 | TNKS (0.35) | KDM4ESMN1; SMN2PRKDCMAPTALDH1A1 | |
| SCHEMBL14860683 | 0.66 | CRBN (0.49) | KDM4ESMN1; SMN2ALDH1A1POLBHSD17B10 | |
| SCHEMBL11154155 | 0.66 | KMT2A (0.40) | KDM4EHTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL21047591 | 0.65 | PRKDC (0.40) | KDM4EHTTKMT2ASMN1; SMN2PRKDC | |
| SCHEMBL31300122 | 0.64 | AKR1C3 (0.40) | KMT2ASMN1; SMN2POLBMEN1HSD17B10 | |
| SCHEMBL849461 | 0.63 | L3MBTL1 (0.57) | KMT2AMAPTALDH1A1MEN1L3MBTL1 | |
| SCHEMBL39726 | 0.63 | MAPT (0.49) | KDM4EKMT2ASMN1; SMN2PRKDCMAPT | |
| SCHEMBL21047699 | 0.63 | PRKDC (0.35) | KDM4EHTTKMT2ASMN1; SMN2PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3682947-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | GB006, Inc. (US) | 2020-07-22 | — | — | EP | disclosed |
| EP-3243821-B1 | PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 | GB006 INC (US) | 2020-02-26 | — | — | EP | disclosed |
| CN-106038558-B | Compounds and methods for modulating integrin CD11b/CD18 | GB006公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-3243821-A1 | PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 | Adhaere Pharamaceuticals, Inc. (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-2591092-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | Adhaere Pharamaceuticals, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |