Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264505 | 0.76 | PIM1 (0.46) | MAPTALDH1A1POLBSMN1; SMN2GAA | |
| SCHEMBL9489951 | 0.73 | KDM4E (0.37) | MAPTALDH1A1POLBCYP1A2SMN1; SMN2 | |
| SCHEMBL40342 | 0.70 | TNKS (0.35) | MAPTALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL11289799 | 0.70 | ALDH1A1 (0.39) | MAPTALDH1A1POLBGPR6MAP3K5 | |
| SCHEMBL39566 | 0.69 | CNR1 (0.34) | MAPTALDH1A1POLBTSHRCYP1A2 | |
| SCHEMBL146714 | 0.68 | NPC1 (0.56) | MAPTALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL5029237 | 0.67 | ADRB1 (0.47) | ALDH1A1KDM4E | |
| SCHEMBL30590077 | 0.66 | NPC1 (0.38) | MAPTALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL11785886 | 0.66 | MAPT (1.00) | MAPTALDH1A1POLBGPR6TSHR | |
| SCHEMBL8381345 | 0.66 | MAP3K5 (0.36) | MAPTALDH1A1POLBMAP3K5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3682947-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | GB006, Inc. (US) | 2020-07-22 | — | — | EP | disclosed |
| EP-3243821-B1 | PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 | GB006 INC (US) | 2020-02-26 | — | — | EP | disclosed |
| CN-106038558-B | Compounds and methods for modulating integrin CD11b/CD18 | GB006公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-3243821-A1 | PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 | Adhaere Pharamaceuticals, Inc. (US) | 2017-11-15 | — | — | EP | disclosed |
| CN-106038558-A | Compounds and methods for regulating integrin CD11B/CD18 | 阿德黑雷制药公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-103189500-B | Compounds and methods for modulating integrin CD11b/CD18 | 阿德黑雷制药公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-103189500-A | Compounds and methods for modulating integrin CD11b/CD18 | ADHAERE PHARAMACEUTICALS INC | 2013-07-03 | — | — | CN | disclosed |
| EP-2591092-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | Adhaere Pharamaceuticals, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |