Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2333717 | 0.84 | PARP1 (0.39) | BCAT2DYRK1BCSNK1A1TYRO3KDM4E | |
| SCHEMBL28844787 | 0.82 | BCAT2 (0.49) | BCAT2DYRK1BCSNK1A1TYRO3KDM4E | |
| SCHEMBL19520434 | 0.78 | PARP1 (0.44) | DYRK1BKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL5254258 | 0.77 | G6PD (0.44) | KDM4EALDH1A1MAPTPKMYT1MAPK1 | |
| SCHEMBL17026046 | 0.75 | ALDH1A1 (0.46) | KDM4EADRA1AALDH1A1MAPTPKMYT1 | |
| SCHEMBL1095334 | 0.74 | IDO1 (0.51) | KDM4ENPC1RAB9AADRA1DADRA1A | |
| SCHEMBL1529793 | 0.73 | ALDH1A1 (0.40) | ALDH1A1MAPTSCN9APKMYT1 | |
| SCHEMBL210767 | 0.72 | BCAT2 (0.74) | BCAT2DYRK1BCSNK1A1TYRO3KDM4E | |
| SCHEMBL30514077 | 0.72 | BCAT2 (0.74) | BCAT2DYRK1BCSNK1A1TYRO3KDM4E | |
| SCHEMBL4531962 | 0.72 | BCAT2 (0.47) | BCAT2DYRK1BCSNK1A1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346816-A2 | COMPOUNDS FOR USE IN A METHOD FOR TREATING AN AUTOIMMUNE AND INFLAMMATORY DISEASE | Cellestia Biotech AG (CH) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022253794-A2 | METHOD FOR TREATING AN AUTOIMMUNE AND INFLAMMATORY DISEASE | CELLESTIA BIOTECH AG (CH) | 2022-12-08 | — | — | WO | disclosed |
| US-8101612-B2 | N-3-isoxazolyl-4-methyl-3-(1-((1-methylethyl)oxy)-6-phthalazinyl)benzamide; p38 kinase inhibitor; antiinflammatory, analgesic agent; rheumatoid arthritis, osteoporosis, leukemia, psoriasis, Crohn's disease, rhinitis, ulcerative colitis, dermatitis, asthma, Alzheimer's disease, type I and II diabetes | AMGEN INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-7700593-B2 | Imidazo- and triazolo-pyridine compounds and methods of use thereof | AMGEN INC. (US) | 2010-04-20 | — | — | US | disclosed |
| US-20080161303-A1 | Imidazo- and triazolo-pyridine compounds and methods of use thereof | AMGEN INC. (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080119468-A1 | Phthalazine, aza-and diaza-phthalazine compounds and methods of use | AMGEN INC. (US) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119468-A1 | Phthalazine, aza-and diaza-phthalazine compounds and methods of use | DAPK2, CDK2, DAPK1 | BCAT2 3850/4885DYRK1B 1088/4885CSNK1A1 85/4885 |
| US-20080161303-A1 | Imidazo- and triazolo-pyridine compounds and methods of use thereof | MAPK1, MAP3K1, MAP3K7 | BCAT2 2125/4885DYRK1B 704/4885CSNK1A1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.