Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17026046 | 0.84 | ALDH1A1 (0.46) | MYCHDAC8ALDH1A1MAPTPKMYT1 | |
| SCHEMBL19462917 | 0.78 | ALDH1A1 (0.41) | HDAC8ADORA2AADORA1ALDH1A1MAPT | |
| SCHEMBL396726 | 0.77 | BCAT2 (0.47) | HDAC8ALDH1A1MAPTPKMYT1MAPK1 | |
| SCHEMBL9851131 | 0.75 | G6PD (0.65) | G6PDCASP7CASP6MYCNAPRT | |
| SCHEMBL29463923 | 0.73 | ALDH1A1 (0.37) | HDAC8ADORA2AADORA1ALDH1A1MAPT | |
| SCHEMBL22039156 | 0.72 | ALDH1A1 (0.39) | ALDH1A1MAPTCOMTKDM4E | |
| SCHEMBL16277376 | 0.72 | CSNK2A1 (0.45) | ALDH1A1MAPTMEN1POLBKMT2A | |
| SCHEMBL17744802 | 0.71 | G6PD (0.61) | G6PDCASP7CASP6MYCHDAC8 | |
| SCHEMBL16962654 | 0.71 | KDM4E (0.41) | MYCHDAC8ALDH1A1MAPTMEN1 | |
| SCHEMBL9902958 | 0.71 | MAPT (0.37) | HDAC8ALDH1A1MAPTCOMTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807426-A2 | SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Cytovia, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006041900-A2 | SUBSTITUTED N-ARYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA, INC. (US) | 2006-04-20 | — | — | WO | disclosed |