Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3172381 | 1.00 | TSHR (0.44) | TSHRKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3181486 | 0.85 | LMNA (0.45) | TSHRKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3968856 | 0.85 | LMNA (0.45) | TSHRKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3172001 | 0.82 | SMN1; SMN2 (0.42) | TSHRKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3973901 | 0.82 | SMN1; SMN2 (0.42) | TSHRKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3663297 | 0.82 | HCRTR1 (0.36) | TSHRKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3175124 | 0.80 | RAB9A (0.51) | TSHRKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL3182055 | 0.80 | RAB9A (0.51) | TSHRKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL3171002 | 0.80 | RAB9A (0.51) | TSHRKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL3545410 | 0.78 | SPR (0.50) | TSHRKMT2AMEN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051977-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 | Amgen Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008011453-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLβ-HSD-1 | AMGEN INC. (US) | 2008-01-24 | — | — | WO | disclosed |