Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25822303 | 0.85 | KDM4E (0.49) | MTNR1AMTNR1BF10HPGDKDM4E | |
| SCHEMBL4572134 | 0.84 | KDM4E (0.48) | MTNR1AMTNR1BF10HPGDKDM4E | |
| SCHEMBL8901248 | 0.84 | KDM4E (0.62) | MTNR1AMTNR1BHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL441754 | 0.82 | MTNR1A (0.52) | MTNR1AMTNR1BF10HPGDSMN1; SMN2 | |
| SCHEMBL2208524 | 0.81 | CA1 (0.56) | MTNR1AMTNR1BF10KDM4E | |
| SCHEMBL9953676 | 0.81 | L3MBTL1 (0.53) | MTNR1AMTNR1BF10HPGDKDM4E | |
| SCHEMBL25380954 | 0.80 | DRD2 (0.60) | MTNR1AMTNR1BF10HPGDSMN1; SMN2 | |
| SCHEMBL2206953 | 0.80 | TAAR1 (0.50) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29818781 | 0.80 | TAAR1 (0.50) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4569111 | 0.79 | KDM4E (0.47) | MTNR1AMTNR1BF10HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |