Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | AXL | P30530 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969736 | 0.80 | AURKA (0.37) | NISCHKDRAXLTP53GAA | |
| SCHEMBL3965914 | 0.75 | JAK2 (0.48) | PDE4BTP53GAAMAPTCDK2 | |
| SCHEMBL13881534 | 0.73 | JAK2 (0.45) | PDE4BCDK1KDRAXLPDE4D | |
| SCHEMBL3963688 | 0.73 | JAK2 (0.59) | CDK1TP53MAPTCCNT1CDK4 | |
| SCHEMBL10960475 | 0.71 | NISCH (0.46) | NISCH | |
| SCHEMBL13881483 | 0.69 | AXL (0.64) | KDRAXLPDE4DCDK4CDK7 | |
| SCHEMBL3967433 | 0.68 | AXL (0.44) | PDE4BAXLJAK2JAK3 | |
| SCHEMBL2051189 | 0.68 | NISCH (0.42) | NISCHMAPT | |
| SCHEMBL3963849 | 0.67 | CYP2A6 (0.42) | TP53GAAMAPT | |
| SCHEMBL2433331 | 0.65 | BRD4 (0.63) | KDRAXLPDE4DCDK4CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |