SCHEMBL396936

SCHEMBL396936

C=C(C)C(=O)OCCC([SiH3])(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.43
TSHR P16473 3/20 0.42
ALDH1A1 P00352 2/20 0.38
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
HTT P42858 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL35614 0.90 TSHR (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL734093 0.84 THRB (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL393525 0.83 TSHR (0.40) THRBTSHRALDH1A1
SCHEMBL4454148 0.83 THRB (0.46) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL9143876 0.79 THRB (0.42) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL29011419 0.78 TSHR (0.41) THRBTSHRALDH1A1
SCHEMBL17922843 0.78 THRB (0.53) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL397195 0.78 TSHR (0.46) THRBTSHRALDH1A1
SCHEMBL9469046 0.77 TSHR (0.41) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL17374783 0.77 TSHR (0.38) THRBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113166340-A Hydrogel composition 眼科公司 2021-07-23 CN claimed
CN-114207050-A Composite particles comprising a hydrophobic dye and an amphiphilic block copolymer and their use in optical applications 史密斯实验室公司 2022-03-18 CN disclosed
CN-113166340-A Hydrogel composition 眼科公司 2021-07-23 CN disclosed
CN-109070503-B Colored contact lenses and methods of making same 望隼科技股份有限公司 2021-03-05 CN disclosed
CN-110753588-A Graphene reinforced and engineered materials for membrane contact switches and other flexible electronic structures 阿尔法装配解决方案公司 2020-02-04 CN disclosed
CN-105209936-B Optical element for correcting color blindness 日东电工株式会社 2020-01-14 CN disclosed
CN-104024891-A Optical element for correcting color blindness NITTO DENKO CORP 2014-09-03 CN disclosed
US-8110697-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-02-07 US disclosed
US-8101789-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-01-24 US disclosed
US-20100041909-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-18 US disclosed
US-20100029972-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-04 US disclosed