Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.46 |
| ▸ | FURIN | P09958 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875463 | 0.82 | SLC6A4 (0.56) | SLC6A4SLC6A2SLC6A3CHRNA7KMT2A | |
| Hydrochloric Acid SCHEMBL1164515 | 0.81 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3CHRNA7KMT2A | |
| Hydrochloric Acid SCHEMBL1164513 | 0.81 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3CHRNA7KMT2A | |
| SCHEMBL3028371 | 0.78 | PARP10 (0.93) | PARP10SENP8SENP6OPRK1KCNH2 | |
| SCHEMBL4798997 | 0.78 | PARP10 (0.73) | PARP10SENP8SENP6OPRK1KCNH2 | |
| SCHEMBL9596396 | 0.77 | PARP10 (0.67) | PARP10SLC6A4SLC6A2SLC6A3SENP8 | |
| SCHEMBL19381882 | 0.77 | PARP10 (0.90) | PARP10SENP8SENP6OPRK1KCNH2 | |
| Hydrochloric Acid SCHEMBL3636392 | 0.76 | PARP10 (0.71) | PARP10SENP8SENP6OPRK1KCNH2 | |
| SCHEMBL4176017 | 0.76 | OPRK1 (0.71) | PARP10SLC6A2SLC6A3SENP8SENP6 | |
| SCHEMBL3960825 | 0.76 | OPRK1 (0.71) | PARP10SLC6A2SLC6A3SENP8SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357686-B2 | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2013-01-22 | — | — | US | disclosed |
| US-20090258881-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
| US-20090258872-A1 | USE OF ARYL-SUBSTITUTED POLYCYCLIC AMINES AS MEDICAMENTS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
| US-7569583-B2 | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-08-04 | — | — | US | disclosed |
| EP-1781656-B1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-19 | — | — | EP | disclosed |
| US-20070197584-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197584-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | PAH, NAT1, AADAT | PARP10 2175/4885SLC6A4 250/4885SLC6A2 118/4885 |
| US-20090258872-A1 | USE OF ARYL-SUBSTITUTED POLYCYCLIC AMINES AS MEDICAMENTS | AADAT, NAT1, OAT | PARP10 2121/4885SLC6A4 307/4885SLC6A2 74/4885 |
| US-20090258881-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | PAH, NAT1, AADAT | PARP10 2175/4885SLC6A4 250/4885SLC6A2 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.