⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945664 | 0.79 | — | — | |
| SCHEMBL3970002 | 0.79 | — | — | |
| SCHEMBL11053945 | 0.79 | TSHR (0.40) | — | |
| SCHEMBL8515614 | 0.76 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL19207193 | 0.75 | — | — | |
| SCHEMBL8428847 | 0.72 | ALDH1A1 (0.44) | — | |
| SCHEMBL19938200 | 0.72 | GSR (0.34) | — | |
| SCHEMBL260743 | 0.72 | NLRP3 (0.36) | — | |
| SCHEMBL259449 | 0.72 | NLRP3 (0.36) | — | |
| SCHEMBL18025581 | 0.72 | FBP1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11926631-B2 | Method of treating cancer using amanitin derivatives | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2024-03-12 | — | — | US | disclosed |
| US-20230233703-A1 | AMANITIN CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-07-27 | — | — | US | disclosed |
| US-11702451-B2 | Method for synthesizing amanitins | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-07-18 | — | — | US | disclosed |
| US-20230220001-A1 | METHOD FOR SYNTHESIS OF THIOETHER-CONTAINING PEPTIDES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-07-13 | — | — | US | disclosed |
| EP-4161946-A1 | METHOD FOR SYNTHESIS OF THIOETHER-CONTAINING PEPTIDES | Heidelberg Pharma Research GmbH (DE) | 2023-04-12 | — | — | EP | disclosed |
| US-11590238-B2 | Amanitin conjugates | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-02-28 | — | — | US | disclosed |
| CN-115715294-A | Method for synthesizing thioether-containing peptides | 海德堡医药研究有限责任公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-110099698-B | Amanitin antibody conjugates | 海德堡医药研究有限责任公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-110997676-B | Novel method for synthesizing amanitine | 海德堡医药研究有限责任公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-111051310-B | Novel method for synthesizing amanitin | 海德堡医药研究有限责任公司 | 2022-11-08 | — | — | CN | disclosed |
| US-20190328899-A1 | AMANITIN ANTIBODY CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2019-10-31 | — | — | US | disclosed |
| EP-3222292-A1 | AMANITIN CONJUGATES | Heidelberg Pharma GmbH (DE) | 2017-09-27 | — | — | EP | disclosed |
| US-7544699-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7501538-B2 | Aryl and heteroaryl compounds, compositions and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-20070254916-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | MJALLI ADNAN M | 2007-11-01 | — | — | US | disclosed |
| US-7122580-B2 | Aryl and heteroaryl compounds and methods to modulate coagulation | TRANSTECH PHARMA, INC. (US) | 2006-10-17 | — | — | US | disclosed |
| US-20050059713-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | disclosed |
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | disclosed |
| US-20050049310-A1 | Aryl and heteroaryl compounds, compositions and methods of use | VTVX HOLDINGS I LLC | 2005-03-03 | — | — | US | disclosed |