Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27684838 | 0.83 | NAAA (0.33) | TP53L3MBTL1CYP19A1 | |
| SCHEMBL3607831 | 0.76 | TP53 (0.50) | TP53L3MBTL1ACE | |
| SCHEMBL27684837 | 0.73 | KMT2A (0.38) | TP53L3MBTL1 | |
| SCHEMBL13543202 | 0.69 | NPC1 (0.42) | — | |
| SCHEMBL14752946 | 0.69 | CCR2 (0.45) | L3MBTL1 | |
| SCHEMBL27665848 | 0.66 | ALDH1A1 (0.34) | TP53L3MBTL1CHRM2CHRM4CHRM1 | |
| SCHEMBL9817590 | 0.64 | TP53 (0.54) | TP53L3MBTL1CYP19A1 | |
| SCHEMBL9817586 | 0.64 | TP53 (0.54) | TP53L3MBTL1CYP19A1 | |
| SCHEMBL9817595 | 0.64 | TP53 (0.54) | TP53L3MBTL1CYP19A1 | |
| SCHEMBL12208661 | 0.64 | LIPA (0.44) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748982-B1 | (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-1748982-A1 | (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005108362-A1 | (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2005-11-17 | — | — | WO | disclosed |