Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | GRM8 | O00222 | 3/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.43 |
| ▸ | GRM6 | O15303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842764 | 0.84 | GRM8 (0.47) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL31584827 | 0.83 | ALDH1A1 (0.51) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL14380435 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL27085813 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL12089924 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL31347515 | 0.77 | ALDH1A1 (0.51) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL7978440 | 0.77 | GRM8 (0.54) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL7976515 | 0.76 | ALDH1A1 (0.55) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL29192875 | 0.76 | GRM8 (0.52) | ALDH1A1TDP1TUBB4ATUBBTUBA3C | |
| SCHEMBL31480878 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TDP1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572778-B2 | recognize and bind the tubulin site: antitubulin; useful for treating pathological states which arise from or are exacerbated by cell proliferation as anticancer and/or antiangiogenic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-08-11 | — | — | US | disclosed |
| US-20060160778-A1 | recognize and bind the tubulin site: antitubulin; useful for treating pathological states which arise from or are exacerbated by cell proliferation as anticancer and/or antiangiogenic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160778-A1 | recognize and bind the tubulin site: antitubulin; useful for treating pathological states which arise from or are exacerbated by cell proliferation as anticancer and/or antiangiogenic activity | TUBB, TUBB1, TUBB6 | ALDH1A1 4377/4885TDP1 1419/4885TUBB4A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.