SCHEMBL3971239

SCHEMBL3971239

O=C(O)c1ccccc1-c1cccc(Cc2ccccc2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACMSD Q8TDX5 1/20 0.63
PTPN1 P18031 5/20 0.56
PLA2G2A P14555 7/20 0.55
PLA2G10 O15496 6/20 0.55
HNF4A P41235 2/20 0.54
SLCO1B1 Q9Y6L6 1/20 0.52
PTPN2 P17706 2/20 0.51
PTPN6 P29350 2/20 0.51
PLA2G1B P04054 1/20 0.49
PLA2G5 P39877 1/20 0.49
PLA2G2C Q5R387 1/20 0.49
PLA2G12B Q9BX93 1/20 0.49
PLA2G12A Q9BZM1 1/20 0.49
PLA2G2F Q9BZM2 1/20 0.49
PLA2G3 Q9NZ20 1/20 0.49
PLA2G2E Q9NZK7 1/20 0.49
PLA2G2D Q9UNK4 1/20 0.49
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22071096 0.87 ACMSD (0.60) ACMSDPTPN1HNF4APTPN2PTPN6
SCHEMBL18414391 0.85 BCL2 (0.58) ACMSDHNF4ANPC1RAB9ASMN1; SMN2
SCHEMBL19237016 0.85 CFD (0.50) ACMSDHNF4ANPC1RAB9ASMN1; SMN2
SCHEMBL9341892 0.85 LTB4R2 (0.49) ACMSDPTPN1HNF4ANPC1RAB9A
Hydrochloric Acid SCHEMBL20593581 0.84 CFD (0.49) ACMSDHNF4ANPC1RAB9ASMN1; SMN2
SCHEMBL689031 0.84 HNF4A (0.62) ACMSDPTPN1HNF4ANPC1RAB9A
SCHEMBL7252300 0.80 ACMSD (0.59) ACMSDPTPN1HNF4ANPC1RAB9A
SCHEMBL7407371 0.80 HNF4A (0.73) PTPN1HNF4ANPC1RAB9ASMN1; SMN2
SCHEMBL31688936 0.79 MAPK1 (0.64)
SCHEMBL27362497 0.79 CYP4F2 (0.50) RAB9ACYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4309421-A Stabilized parenterally administrable solutions A. NATTERMANN & CIE. GMBH (DE) 1982-01-05 US claimed
EP-2065047-A1 Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein Board of Regents, The University of Texas System (US) 2009-06-03 EP disclosed
EP-1214940-B1 Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein UNIV TEXAS (US) 2009-03-11 EP disclosed
EP-1214940-A1 Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-06-19 EP disclosed
EP-0805684-B1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN UNIV TEXAS (US) 2002-06-12 EP disclosed
US-5955451-A NONSTEROID ANTIINFLAMMATORY AGENTS COMPLEXED WITH ZWITTERIONS OR PHOSPHOLIPIDS FOR NONIRRITATION OF GASTROINTESTINAL SYSTEMS AND ANTIPYRETICS THE UNIVERSITY OF TEXAS SYSTEM BOARD OF REGENTS 1999-09-21 US disclosed
WO-1998013073-A9 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN 1998-08-06 WO disclosed
EP-0805684-A4 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN UNIV TEXAS (US) 1998-08-05 EP disclosed
US-5763422-A Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-06-09 US disclosed
WO-1998013073-A1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-04-02 WO disclosed
EP-0805684-A2 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1997-11-12 EP disclosed
WO-1996022780-A1 METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1996-08-01 WO disclosed
US-4528193-A Inflammation-preventing pharmaceutical composition of oral administration A. NATTERMAN & CIE. GMBH (DE) 1985-07-09 US disclosed
US-4421747-A PHOSPHOLIPID AND DERIVATIVE OF PHENYLACETIC OR PHENYLPROPIONIC ACID A. NATTERMANN & CIE. GMBH (DE) 1983-12-20 US disclosed
US-4378354-A CONSISTING OF A PHOSPHOLIPID AND SALICYLIC ACID OR DERIVATIVE A. NATTERMANN & CIE. GMBH (DE) 1983-03-29 US disclosed
US-4369182-A Inflammation-preventing pharmaceutical composition of oral administration A. NATTERMANN & CIE GMBH (DE) 1983-01-18 US disclosed
US-4332795-A INDOLE COMPOUND AND PHOSPHOLIPID A. NATTERMANN & CIE. GMBH (DE) 1982-06-01 US disclosed
US-4309421-A Stabilized parenterally administrable solutions A. NATTERMANN & CIE. GMBH (DE) 1982-01-05 US disclosed