Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 5/20 | 0.50 |
| ▸ | HNF4A | P41235 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20593581 | 0.98 | CFD (0.49) | CFDHNF4APLGPLAUMYC | |
| SCHEMBL5580865 | 0.89 | CFD (0.45) | CFDHNF4APLGPLAUMYC | |
| SCHEMBL20946451 | 0.87 | BCAT2 (0.61) | CFDPLGPLAUBCAT2CHRNB2 | |
| SCHEMBL3971239 | 0.85 | ACMSD (0.63) | HNF4ANPC1RAB9ASMN1; SMN2ACMSD | |
| SCHEMBL22071096 | 0.85 | ACMSD (0.60) | HNF4ABCAT2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3629995 | 0.85 | LTB4R2 (0.57) | HNF4AMYCBCAT2FOLH1LTB4R2 | |
| SCHEMBL9341892 | 0.84 | LTB4R2 (0.49) | HNF4ANPC1RAB9ASMN1; SMN2ACMSD | |
| SCHEMBL18414391 | 0.84 | BCL2 (0.58) | HNF4AMYCNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6179887 | 0.83 | LTB4R2 (0.56) | HNF4AMYCBCAT2FOLH1LTB4R2 | |
| SCHEMBL28116797 | 0.83 | CFD (0.44) | CFDPLGPLAUBCAT2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714648-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-08-16 | — | — | EP | disclosed |
| CN-1064042-C | Intermediate of benzazepine derivative | YAMANOUCHI PHARMA CO LTD (JP) | 2001-04-04 | — | — | CN | disclosed |
| CN-1040748-C | Benzazepine derivatives, pharmaceutical compositions and intermediates thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1998-11-18 | — | — | CN | disclosed |
| CN-1198437-A | Intermediate of benzazepine derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1998-11-11 | — | — | CN | disclosed |
| CN-1129934-A | Benzazepine derivatives, pharmaceutical compositions and intermediates thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1996-08-28 | — | — | CN | disclosed |