Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.47 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.47 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PNMT | P11086 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30062398 | 1.00 | HSPB1 (0.56) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL9367150 | 0.86 | AKR1C3 (0.50) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL10498181 | 0.85 | HSPB1 (0.52) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL8643566 | 0.83 | HSPB1 (0.51) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL1275605 | 0.83 | HSPB1 (0.51) | HSPB1KMT2AMAPTTDP1LMNA | |
| SCHEMBL7823977 | 0.83 | KMT2A (0.53) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL10916019 | 0.83 | CYP1A2 (0.52) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL1130254 | 0.81 | ALDH1A1 (0.53) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16959020 | 0.81 | PTPN1 (0.40) | HSPB1ALDH1A1HIF1AMEN1KMT2A | |
| SCHEMBL2311099 | 0.81 | S100A4 (0.42) | HSPB1ALDH1A1MAPTTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115353457-A | Asymmetric carbonic ester and preparation method thereof | 武汉理工大学 | 2022-11-18 | — | — | CN | claimed |
| CN-115353457-A | Asymmetric carbonic ester and preparation method thereof | 武汉理工大学 | 2022-11-18 | — | — | CN | disclosed |
| CN-107501099-B | Modulators of ATP-binding cassette transporters | 沃泰克斯药物股份有限公司 | 2021-03-19 | — | — | CN | disclosed |
| EP-3705477-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3216787-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2643496-B1 | USE OF THIN FILMS OF MESOPOROUS SILICA AS SENSITIVE COMPONENTS IN GRAVIMETRIC SENSORS FOR DETERMINING THE CONCENTRATION OF NITRATE COMPOUNDS IN GASES | COMMISSARIAT L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2017-04-12 | — | — | EP | disclosed |
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | disclosed |
| US-20080044910-A1 | Chemical Sensors Comprising Fluorescent Conjugated Polymers as Sensitive Materials, and Their use in the Detection or Assaying of Nitro Compounds | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-02-21 | — | — | US | disclosed |
| EP-1817363-A1 | CHEMICAL SENSORS COMPRISING ANILINE POLYSILOXANES AS SENSITIVE MATERIALS AND USE THEREOF FOR DETECTING OF ASSAYING NITRO COMPOUNDS | Commissariat à l'Energie Atomique (FR) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007075946-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| EP-1733210-A1 | CHEMICAL SENSORS COMPRISING FLUORESCENT CONJUGATED POLYMERS AS SENSITIVE MATERIALS, AND THE USE THEREOF FOR THE DETECTION OR DOSAGE OF NITRATED COMPOUNDS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1731548-A1 | Use of fluorescent polysiloxanes in chemical sensors for detection or dosage of nitrated compounds | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2006-12-13 | — | — | EP | disclosed |
| WO-2006037921-A1 | CHEMICAL SENSORS COMPRISING ANILINE POLYSILOXANES AS SENSITIVE MATERIALS AND USE THEREOF FOR DETECTING OF ASSAYING NITRO COMPOUNDS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2006-04-13 | — | — | WO | disclosed |
| US-20060074075-A1 | including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders | VERTEX PHARMACEUTICALS INCORPORATED | 2006-04-06 | — | — | US | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |
| WO-2005103653-A1 | CHEMICAL SENSORS COMPRISING FLUORESCENT CONJUGATED POLYMERS AS SENSITIVE MATERIALS, AND THE USE THEREOF FOR THE DETECTION OR DOSAGE OF NITRATED COMPOUNDS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | HSPB1 392/4885ALDH1A1 2165/4885HIF1A 736/4885 |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | HSPB1 392/4885ALDH1A1 2165/4885HIF1A 736/4885 |
| US-20060074075-A1 | including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders | CFTR, ABCC4, ABCC2 | HSPB1 756/4885ALDH1A1 2221/4885HIF1A 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.