Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.40 |
| ▸ | EP300 | Q09472 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | KAT2A | Q92830 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31252939 | 1.00 | KDM4E (0.40) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL30489898 | 0.77 | AXL (0.42) | KDM4EMAPTLMNAHSP90AA1L3MBTL1 | |
| SCHEMBL2176528 | 0.77 | AXL (0.42) | KDM4EMAPTLMNAHSP90AA1L3MBTL1 | |
| SCHEMBL30338424 | 0.75 | HSP90AA1 (0.42) | KDM4EMAPTLMNAHSP90AA1KAT2B | |
| SCHEMBL22270961 | 0.75 | KDM4E (0.39) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL5279895 | 0.75 | KDM4E (0.38) | KDM4EMAPTLMNAHSP90AA1L3MBTL1 | |
| SCHEMBL2713045 | 0.75 | HSP90AA1 (0.42) | KDM4EMAPTLMNAHSP90AA1KAT2B | |
| SCHEMBL9540944 | 0.75 | KDM4E (0.44) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL12334 | 0.75 | NPC1 (0.43) | KDM4EMAPTLMNAHSP90AA1CCR1 | |
| SCHEMBL23188125 | 0.72 | L3MBTL1 (0.38) | KDM4EMAPTLMNAHSP90AA1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499654-B | Method for synthesizing 3-chloro-thiophene [2, 3-b ] pyridine derivative | 南通诺泰生物医药技术有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-111499654-B | Method for synthesizing 3-chloro-thiophene [2, 3-b ] pyridine derivative | 南通诺泰生物医药技术有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-111499654-A | Method for synthesizing 3-chloro-thiophene [2, 3-b ] pyridine derivative | 南通诺泰生物医药技术有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-111499654-A | Method for synthesizing 3-chloro-thiophene [2, 3-b ] pyridine derivative | 南通诺泰生物医药技术有限公司 | 2020-08-07 | — | — | CN | disclosed |
| US-7557103-B2 | Imidazopyridazine compounds | ELI LILLY AND COMPANY (US) | 2009-07-07 | — | — | US | disclosed |
| US-20080153828-A1 | Imidazopyridazine Compounds | ELI LILLY AND COMPANY | 2008-06-26 | — | — | US | disclosed |
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153828-A1 | Imidazopyridazine Compounds | CRHR1, CRH, CRHR2 | KDM4E 4385/4885MAPT 1548/4885LMNA 4643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.