Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 11/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 11/20 | 0.54 |
| ▸ | GABRP | O00591 | 6/20 | 0.49 |
| ▸ | GABRD | O14764 | 6/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.49 |
| ▸ | GABRE | P78334 | 6/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.49 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.49 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.49 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973806 | 0.79 | TSHR (0.49) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL13883871 | 0.79 | SIRT2 (0.54) | GABRA2GABRB2ALDH1A1MAPTKDM4E | |
| SCHEMBL30712292 | 0.76 | GABRA1 (0.59) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL2201127 | 0.76 | GABRA1 (0.59) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL30712301 | 0.76 | GABRA1 (0.59) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL2881651 | 0.75 | NPC1 (0.48) | GABRA2GABRB2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14255128 | 0.74 | GABRA2 (0.50) | GABRA2GABRB2NPC1 | |
| SCHEMBL2215015 | 0.72 | CNR2 (0.71) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL4962137 | 0.72 | GABRA2 (0.75) | GABRA2GABRB2ALDH1A1MAPTKDM4E | |
| SCHEMBL2945382 | 0.72 | MAOB (0.49) | GABRA2GABRB2GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |