Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.59 |
| ▸ | GABRP | O00591 | 6/20 | 0.59 |
| ▸ | GABRD | O14764 | 6/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.59 |
| ▸ | GABRE | P78334 | 6/20 | 0.59 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.59 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.59 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30712292 | 1.00 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL30712301 | 1.00 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Trifluoroacetic Acid SCHEMBL30366263 | 0.90 | GABRA2 (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28680173 | 0.88 | GABRP (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27449890 | 0.85 | TSHR (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2728132 | 0.83 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL13610176 | 0.83 | ALDH1A1 (0.56) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28006876 | 0.83 | EGLN1 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5161426 | 0.82 | GABRP (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5495291 | 0.82 | ALDH1A1 (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177785-A | A kind of dihydroisoquinoliness compound | 苏州爱科百发生物医药技术有限公司 | 2019-08-27 | — | — | CN | claimed |
| CN-116751200-A | Tricyclic compounds containing substituted pyridones and methods of using the same | 爱彼特生物制药公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-110114071-B | Tricyclic compounds containing substituted pyridones and methods of using the same | 爱彼特生物制药公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-113880063-B | Aluminum removal method for phosphorus iron slag after lithium extraction of waste lithium iron phosphate and preparation method for battery grade iron phosphate | 广东光华科技股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-113999224-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-114014854-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-109715624-B | Novel therapeutic agents for the treatment of HBV infection | 广州麓鹏制药有限公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111943946-B | Dihydroquinazinone carboxylic acid compound containing nitrogen heterocyclic segment and application thereof | 中国医学科学院医药生物技术研究所 | 2022-07-01 | — | — | CN | disclosed |
| CN-110177785-B | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-114014854-A | Dihydroisoquinoline compound | 苏州爱科百发生物医药技术有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-1031266-C | Process for preparation of heterocycle ether derivatives | ZENECA LTD (GB) | 1996-03-13 | — | — | CN | disclosed |
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |
| CN-1013115-B | PROCESS FOR PREPARING PYRIMIDOISOQUINOLINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-07-10 | — | — | CN | disclosed |
| CN-1046903-A | Process for preparing heterocyclic ether derivatives | ICI PLC (GB) | 1990-11-14 | — | — | CN | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |
| EP-0381375-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-08 | — | — | EP | disclosed |
| CN-85102138-A | The preparation method of pyrimidoisoquinolinederivatives derivatives | — | 1986-04-10 | — | — | CN | disclosed |