SCHEMBL397214

SCHEMBL397214

C=C(C)C(=O)Nc1cccc(S(=O)(=O)N(CC)CC)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.61
ALDH1A1 P00352 8/20 0.61
SMN1; SMN2 Q16637 7/20 0.61
MEN1 O00255 4/20 0.61
KMT2A Q03164 4/20 0.61
MAPK1 P28482 2/20 0.61
HSP90AA1 P07900 1/20 0.61
LMNA P02545 8/20 0.60
GAA P10253 2/20 0.60
HTT P42858 2/20 0.60
NPSR1 Q6W5P4 2/20 0.60
XBP1 P17861 1/20 0.60
PAX8 Q06710 1/20 0.60
TSHR P16473 2/20 0.58
RAB9A P51151 2/20 0.58
BRD4 O60885 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
KDM4E B2RXH2 1/20 0.53
NPC1 O15118 1/20 0.53
NR2F2 P24468 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL397453 0.85 KMT2A (0.59) MAPTALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL396051 0.83 MEN1 (0.57) MAPTALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL7597973 0.82 TDP1 (0.64) MAPTALDH1A1SMN1; SMN2MAPK1LMNA
SCHEMBL1811660 0.80 TDP1 (0.62) MAPTSMN1; SMN2LMNAGAAHTT
SCHEMBL393848 0.80 TDP1 (0.55) MAPTALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL396033 0.79 CA1 (0.61) MAPTTDP1
SCHEMBL394315 0.78 ALDH1A1 (0.53) MAPTALDH1A1SMN1; SMN2KMT2ALMNA
SCHEMBL393893 0.78 TDP1 (0.59) MAPTALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL1098272 0.76 TDP1 (0.79) ALDH1A1RAB9ATDP1KDM4E
SCHEMBL392740 0.76 ALDH1A1 (0.51) MAPTALDH1A1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120146264-A1 RESIN COMPOSITION FOR LASER ENGRAVING, RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND PROCESS FOR PRODUCING SAME, AND PROCESS FOR MAKING RELIEF PRINTING PLATE FUJIFILM CORPORATION (JP) 2012-06-14 US disclosed
US-8101332-B2 Negative-working lithographic printing plate precursor and method of lithographic printing using same FUJIFILM CORPORATION (JP) 2012-01-24 US disclosed
EP-1972440-B1 Negative lithographic printing plate precursor and lithographic printing method using the same FUJIFILM CORP (JP) 2010-06-23 EP disclosed
US-20090246688-A1 NEGATIVE-WORKING LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING USING SAME FUJIFILM CORPORATION (JP) 2009-10-01 US disclosed
EP-2105298-A1 Negative-working lithographic printing plate precursor and method of lithographic printing using same Fujifilm Corporation (JP) 2009-09-30 EP disclosed
US-20080233516-A1 NEGATIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR AND LITHOGRAPHIC PRINTING METHOD USING THE SAME FUJIFILM CORPORATION (JP) 2008-09-25 US disclosed
EP-1972440-A2 Negative lithographic printing plate precursor and lithographic printing method using the same FUJIFILM Corporation (JP) 2008-09-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120146264-A1 RESIN COMPOSITION FOR LASER ENGRAVING, RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND PROCESS FOR PRODUCING SAME, AND PROCESS FOR MAKING RELIEF PRINTING PLATE EIF3L, EIF2B1, EIF2B5 MAPT 1418/4885ALDH1A1 1302/4885SMN1; SMN2 815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.