Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170567 | 0.86 | KDM1A (0.48) | NOD2NOD1MEN1KMT2AL3MBTL1 | |
| SCHEMBL29853941 | 0.85 | TP53 (0.43) | NOD2NOD1KDM4EMEN1KMT2A | |
| SCHEMBL28615205 | 0.84 | NOD2 (0.51) | NOD2NOD1KDM4EADORA3MEN1 | |
| SCHEMBL6706688 | 0.84 | NOD2 (0.51) | NOD2NOD1KDM4EADORA3MEN1 | |
| SCHEMBL28208532 | 0.83 | TP53 (0.42) | NOD2NOD1KDM4EMEN1KMT2A | |
| SCHEMBL6988991 | 0.83 | NOD2 (0.71) | NOD2NOD1KDM4EADORA3MEN1 | |
| SCHEMBL4056238 | 0.83 | NOD2 (0.50) | NOD2NOD1KDM4EADORA3MEN1 | |
| SCHEMBL5136650 | 0.81 | NOD2 (0.55) | NOD2NOD1KDM4EMEN1KMT2A | |
| SCHEMBL5713778 | 0.81 | NR1H2 (0.57) | NR1H2 | |
| SCHEMBL30711377 | 0.81 | NR1H2 (0.57) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2847164-A1 | COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF | The University of Utah Research Foundation (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013169396-A1 | COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF | THE UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-11-14 | — | — | WO | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |