Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.55 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988991 | 0.87 | NOD2 (0.71) | NOD2NOD1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3972260 | 0.81 | NOD2 (0.53) | NOD2NOD1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4251782 | 0.81 | NR1H2 (0.54) | — | |
| SCHEMBL29725642 | 0.81 | NR1H2 (0.54) | — | |
| SCHEMBL27570092 | 0.79 | DAO (0.49) | NOD2NOD1MAPTCYP1A2MCL1 | |
| SCHEMBL8689345 | 0.79 | KMT2A (0.58) | NOD2NOD1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28615205 | 0.79 | NOD2 (0.51) | NOD2NOD1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6706688 | 0.79 | NOD2 (0.51) | NOD2NOD1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4056238 | 0.78 | NOD2 (0.50) | NOD2NOD1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24894603 | 0.77 | NOD2 (0.62) | NOD2NOD1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904477-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006688-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |