Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968473 | 0.93 | MAPK1 (0.43) | SMN1; SMN2KMT2ACFDTPSB2TSHR | |
| SCHEMBL3964690 | 0.93 | CYP1A2 (0.43) | SMN1; SMN2KMT2ACFDTPSB2TSHR | |
| SCHEMBL3967162 | 0.88 | ALDH1A1 (0.47) | SMN1; SMN2KMT2ACFDTPSB2TSHR | |
| SCHEMBL3972169 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2ACFDTPSB2TSHR | |
| SCHEMBL3966429 | 0.86 | TDP1 (0.44) | SMN1; SMN2KMT2ACFDTPSB2TSHR | |
| SCHEMBL3967907 | 0.84 | TSHR (0.52) | SMN1; SMN2KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL24527630 | 0.83 | AOC3 (0.53) | TSHRROCK2ROCK1MAPK1TAAR1 | |
| SCHEMBL382558 | 0.83 | AOC3 (0.53) | TSHRROCK2ROCK1MAPK1TAAR1 | |
| SCHEMBL21507667 | 0.82 | AOC3 (0.50) | ALDH1A1TAAR1AOC3 | |
| SCHEMBL3706818 | 0.81 | TSHR (0.39) | SMN1; SMN2KMT2ACFDTPSB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |