Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967162 | 0.88 | ALDH1A1 (0.47) | KDM4ETSHRSMN1; SMN2KMT2ACFD | |
| SCHEMBL3972169 | 0.87 | SMN1; SMN2 (0.45) | KDM4ETSHRSMN1; SMN2KMT2ACFD | |
| SCHEMBL3972478 | 0.86 | CHEK2 (0.42) | KDM4ETSHRSMN1; SMN2KMT2ACFD | |
| SCHEMBL3968473 | 0.84 | MAPK1 (0.43) | TDP1KDM4ETSHRSMN1; SMN2KMT2A | |
| SCHEMBL3967907 | 0.84 | TSHR (0.52) | TSHRSMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL3964690 | 0.84 | CYP1A2 (0.43) | KDM4ETSHRSMN1; SMN2KMT2ACFD | |
| SCHEMBL28032740 | 0.83 | TDP1 (0.50) | TDP1KDM4EGALR3HSP90AA1NR1H4 | |
| SCHEMBL3706818 | 0.81 | TSHR (0.39) | TDP1KDM4ETSHRSMN1; SMN2KMT2A | |
| SCHEMBL3966532 | 0.81 | KMT2A (0.52) | SMN1; SMN2KMT2ACFDTPSB2 | |
| SCHEMBL24527630 | 0.80 | AOC3 (0.53) | TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |