Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973181 | 0.90 | JAK2 (0.40) | SSTR5DGAT2TACR1 | |
| SCHEMBL3976811 | 0.89 | TP53 (0.43) | SSTR5 | |
| SCHEMBL3970974 | 0.89 | SSTR5 (0.37) | SSTR5BRD4DGAT2TACR1 | |
| SCHEMBL3972951 | 0.89 | RXRA (0.42) | SSTR5SSTR1TACR1 | |
| SCHEMBL3973527 | 0.89 | GABRA5 (0.36) | SSTR5TACR1 | |
| SCHEMBL3972521 | 0.87 | KDM4E (0.38) | SSTR5SSTR1DGAT2TACR1 | |
| SCHEMBL3972553 | 0.87 | SSTR5 (0.45) | SSTR5SSTR1DGAT2 | |
| SCHEMBL3977954 | 0.86 | TACR1 (0.37) | SSTR5SSTR1TOP2ATACR1 | |
| SCHEMBL3972880 | 0.86 | SSTR5 (0.36) | SSTR5TACR1 | |
| SCHEMBL3974558 | 0.81 | GLA (0.41) | SSTR5SSTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |