Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972560 | 0.89 | SSTR5 (0.36) | TACR1SSTR5 | |
| SCHEMBL3973181 | 0.89 | JAK2 (0.40) | GABRA5TACR1SSTR5 | |
| SCHEMBL3970974 | 0.88 | SSTR5 (0.37) | GABRA5TACR1SSTR5 | |
| SCHEMBL3976811 | 0.88 | TP53 (0.43) | GABRA5SSTR5IP6K1 | |
| SCHEMBL3972521 | 0.86 | KDM4E (0.38) | TACR1SSTR5 | |
| SCHEMBL3972951 | 0.85 | RXRA (0.42) | TACR1SSTR5 | |
| SCHEMBL3972553 | 0.85 | SSTR5 (0.45) | SSTR5 | |
| SCHEMBL3977954 | 0.85 | TACR1 (0.37) | TACR1SSTR5 | |
| SCHEMBL3972880 | 0.85 | SSTR5 (0.36) | TACR1SSTR5 | |
| SCHEMBL3977471 | 0.80 | RAB9A (0.40) | SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |