Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970974 | 0.93 | SSTR5 (0.37) | SSTR5KMT2AROCK2MAPTLMNA | |
| SCHEMBL3976811 | 0.93 | TP53 (0.43) | SSTR5KMT2AROCK2GABRA5GAA | |
| SCHEMBL3972560 | 0.90 | SSTR5 (0.36) | SSTR5DGAT2TACR1 | |
| SCHEMBL3973527 | 0.89 | GABRA5 (0.36) | SSTR5GABRA5TACR1 | |
| SCHEMBL3972553 | 0.88 | SSTR5 (0.45) | SSTR5DGAT2 | |
| SCHEMBL3972880 | 0.88 | SSTR5 (0.36) | JAK2SSTR5ROCK2TACR1 | |
| SCHEMBL3972521 | 0.87 | KDM4E (0.38) | SSTR5MAPTDGAT2POLBTACR1 | |
| SCHEMBL3972951 | 0.87 | RXRA (0.42) | SSTR5MAPTTACR1 | |
| SCHEMBL3977954 | 0.86 | TACR1 (0.37) | SSTR5LMNATACR1 | |
| SCHEMBL3977471 | 0.81 | RAB9A (0.40) | L3MBTL1SSTR5KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |