Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977773 | 0.81 | AOC3 (0.43) | CCR5MT-CO2CNR1ATMMEN1 | |
| SCHEMBL22308423 | 0.79 | POLB (0.40) | CCR5MT-CO2ATMMEN1KMT2A | |
| SCHEMBL23564597 | 0.79 | POLB (0.40) | CCR5MT-CO2ATMMEN1KMT2A | |
| SCHEMBL23564596 | 0.76 | ALDH1A1 (0.38) | CCR5MT-CO2MEN1KMT2AHTR2A | |
| SCHEMBL20660957 | 0.75 | AOC3 (0.40) | UTS2RMEN1KMT2AAOC3 | |
| SCHEMBL3972679 | 0.74 | MT-CO2 (0.34) | MT-CO2CNR1ATMMEN1KMT2A | |
| SCHEMBL6435807 | 0.72 | APP (0.32) | — | |
| SCHEMBL6435801 | 0.72 | APP (0.32) | — | |
| SCHEMBL18704218 | 0.71 | FFAR1 (0.36) | UTS2RMEN1KMT2AAOC3 | |
| SCHEMBL18704217 | 0.71 | FFAR1 (0.36) | UTS2RMEN1KMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |