Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23564597 | 0.85 | POLB (0.40) | CCR5MT-CO2MEN1KMT2AREN | |
| SCHEMBL22308423 | 0.85 | POLB (0.40) | CCR5MT-CO2MEN1KMT2AREN | |
| SCHEMBL6133868 | 0.83 | DRD2 (0.46) | MEN1KMT2ALMNA | |
| SCHEMBL6133872 | 0.83 | DRD2 (0.46) | MEN1KMT2ALMNA | |
| SCHEMBL23564596 | 0.82 | ALDH1A1 (0.38) | CCR5MT-CO2MEN1KMT2AGAA | |
| SCHEMBL3972684 | 0.81 | CCR5 (0.35) | AOC3F2RCCR5MT-CO2MEN1 | |
| SCHEMBL4352299 | 0.80 | AOC3 (0.53) | AOC3F2RMT-CO2MEN1KMT2A | |
| SCHEMBL2523360 | 0.78 | AOC3 (0.47) | AOC3F2RMT-CO2MEN1KMT2A | |
| SCHEMBL6135470 | 0.78 | ADRB3 (0.45) | — | |
| SCHEMBL6135475 | 0.78 | ADRB3 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |