Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977769 | 0.83 | MT-CO2 (0.38) | MT-CO2CNR1ATMMEN1KMT2A | |
| SCHEMBL21979525 | 0.75 | LMNA (0.35) | MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL21979522 | 0.75 | LMNA (0.35) | MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL21979527 | 0.75 | LMNA (0.35) | MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL3972684 | 0.74 | CCR5 (0.35) | MT-CO2CNR1ATMMEN1KMT2A | |
| SCHEMBL3969771 | 0.74 | MT-CO2 (0.38) | MT-CO2CNR1ATMMEN1KMT2A | |
| SCHEMBL3973794 | 0.74 | MT-CO2 (0.38) | MT-CO2CNR1MEN1KMT2AGAA | |
| SCHEMBL2573510 | 0.70 | DRD2 (0.39) | CNR1ATMGAACACNA1BALDH1A1 | |
| SCHEMBL3973790 | 0.70 | C5AR1 (0.40) | MT-CO2MEN1KMT2AGAACACNA1B | |
| SCHEMBL29944709 | 0.69 | ABCB1 (0.39) | MEN1KMT2ACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |