Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 17/20 | 0.66 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | MMP16 | P51512 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968057 | 0.94 | PTGDR2 (0.59) | PTGDR2MMP2MMP8MMP12MMP13 | |
| SCHEMBL3965620 | 0.90 | PTGDR2 (0.54) | PTGDR2MMP2MMP8MMP12MMP13 | |
| SCHEMBL3967596 | 0.86 | PTGDR2 (0.50) | PTGDR2 | |
| SCHEMBL3967115 | 0.85 | PTGDR2 (0.48) | PTGDR2 | |
| SCHEMBL3969463 | 0.84 | PTGDR2 (0.47) | PTGDR2MMP2MMP8MMP12MMP13 | |
| SCHEMBL3967747 | 0.82 | PTGDR2 (0.46) | PTGDR2MMP2MMP12MMP13MMP14 | |
| SCHEMBL3967120 | 0.80 | PTGDR2 (0.52) | PTGDR2MMP2MMP12MMP13MMP14 | |
| SCHEMBL3971663 | 0.80 | PTGDR2 (0.45) | PTGDR2 | |
| SCHEMBL3964681 | 0.79 | PTGDR2 (0.46) | PTGDR2MMP2MMP12MMP13MMP14 | |
| SCHEMBL3967113 | 0.79 | PTGDR2 (0.45) | PTGDR2MMP2MMP12MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |