Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968672 | 0.91 | PTGDR2 (0.40) | PTGDR2AKR1C3AKR1C2TRPM8TRPV4 | |
| SCHEMBL3973023 | 0.86 | PTGDR2 (0.66) | PTGDR2 | |
| SCHEMBL3968057 | 0.82 | PTGDR2 (0.59) | PTGDR2 | |
| SCHEMBL3967115 | 0.77 | PTGDR2 (0.48) | PTGDR2PTGDREEF2K | |
| SCHEMBL3965620 | 0.77 | PTGDR2 (0.54) | PTGDR2 | |
| SCHEMBL3971500 | 0.76 | PTGDR2 (0.39) | PTGDR2PTGESALOX5PTGDR | |
| SCHEMBL3970095 | 0.73 | RAPGEF4 (0.43) | PTGDR2PTGESALOX5PTGDRAKR1C3 | |
| SCHEMBL3964356 | 0.73 | PTGDR2 (0.39) | PTGDR2PTGDR | |
| SCHEMBL3969463 | 0.73 | PTGDR2 (0.47) | PTGDR2 | |
| SCHEMBL3967747 | 0.73 | PTGDR2 (0.46) | PTGDR2PTGDREEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |