Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.65 |
| ▸ | KDM1A | O60341 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 8/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | BLM | P54132 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28805458 | 0.87 | PDE5A (0.76) | PDE5ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14262792 | 0.85 | KDM1A (0.78) | PDE5AKDM1ALMNACYP1A2CYP3A4 | |
| SCHEMBL12176196 | 0.84 | PDE5A (0.65) | PDE5ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8615749 | 0.83 | LMNA (0.81) | PDE5AKDM1ALMNACYP1A2CYP3A4 | |
| SCHEMBL3980498 | 0.81 | PDE5A (0.65) | PDE5ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27899415 | 0.81 | MAPK1 (0.63) | PDE5ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2591972 | 0.79 | PDE5A (1.00) | PDE5ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2583256 | 0.77 | PDE5A (0.90) | PDE5ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6671471 | 0.77 | SLC2A1 (0.70) | PDE5ALMNAMAPTTP53HSD17B10 | |
| SCHEMBL7280049 | 0.77 | ALDH1A1 (0.80) | PDE5AKDM1ALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547702-B2 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
| WO-2004030672-A1 | USE OF 4 AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| EP-1318984-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024667-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | SERPINA3, APOL1, MGAT3 | PDE5A 2783/4885KDM1A 4644/4885LMNA 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.