Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973616 | 0.78 | ADORA2A (0.44) | IKBKBPDK1JAK2PDK2PDK3 | |
| SCHEMBL3975493 | 0.77 | MEN1 (0.38) | PDK1AKT1PDK2PDK3PDK4 | |
| SCHEMBL13883474 | 0.71 | TTK (0.57) | JAK2LRRK2 | |
| SCHEMBL10125059 | 0.71 | AKT1 (0.61) | IKBKBAKT1JAK2LRRK2CHUK | |
| SCHEMBL30649183 | 0.71 | AKT1 (0.61) | IKBKBAKT1JAK2LRRK2CHUK | |
| SCHEMBL4236776 | 0.71 | TTK (0.59) | JAK2LRRK2JAK1 | |
| SCHEMBL11889707 | 0.69 | JAK2 (0.50) | IKBKBAKT1JAK2LRRK2CHUK | |
| SCHEMBL3967588 | 0.68 | PGK1 (0.38) | IKBKBPDK1JAK2DYRK1AADORA2A | |
| SCHEMBL3971472 | 0.67 | ADORA2A (0.38) | PDK1JAK2PDK2PDK3PDK4 | |
| SCHEMBL3975335 | 0.66 | CYP2A6 (0.38) | PDK1PDK2PDK3PDK4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |