Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979286 | 0.92 | LMNA (0.51) | RAB9ANPC1MAPTMAPK14MAPK13 | |
| SCHEMBL3978596 | 0.91 | LMNA (0.49) | RAB9ASMN1; SMN2NPC1MAPTAHR | |
| SCHEMBL3980152 | 0.91 | MAPK14 (0.56) | RAB9ASMN1; SMN2NPC1MAPTAHR | |
| SCHEMBL3974469 | 0.90 | MAPK14 (0.46) | RAB9ASMN1; SMN2NPC1MAPTAHR | |
| SCHEMBL3972985 | 0.89 | MAPK14 (0.45) | RAB9ASMN1; SMN2NPC1MAPTAHR | |
| SCHEMBL3974140 | 0.84 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3975609 | 0.84 | SMN1; SMN2 (0.48) | RAB9ASMN1; SMN2MAPTMAPK14MAPK13 | |
| SCHEMBL4084990 | 0.84 | MAPK14 (0.43) | NPC1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3864506 | 0.83 | MAPK14 (0.48) | RAB9ANPC1MAPTMAPK14MAPK13 | |
| SCHEMBL3979999 | 0.83 | RAB9A (0.47) | RAB9ASMN1; SMN2NPC1MAPTAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209451-A1 | HETEROARYLAMINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090209451-A1 | HETEROARYLAMINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090209451-A1 | HETEROARYLAMINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-08-20 | — | — | US | disclosed |
| US-7517878-B2 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | BAYER PHARAMCEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517878-B2 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | BAYER PHARAMCEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517878-B2 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | BAYER PHARAMCEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
| US-20050192294-A1 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192294-A1 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | GPR119, GOT2, IAPP | RAB9A 2873/4885SMN1; SMN2 4413/4885NPC1 303/4885 |
| US-20090209451-A1 | HETEROARYLAMINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | GPR119, GOT2, IAPP | RAB9A 2873/4885SMN1; SMN2 4413/4885NPC1 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.