SCHEMBL3974314

SCHEMBL3974314

CCc1cc(-n2nnc(N)c2-c2cccc3[nH]c(C(C)C)cc23)c(O)cc1O

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.34
DDO Q99489 1/20 0.34
DHFR P00374 1/20 0.34
SLC2A1 P11166 1/20 0.34
HSP90AA1 P07900 13/20 0.33
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 2/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 2/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
GRIN2D O15399 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
GAA P10253 1/20 0.30
PAX8 Q06710 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3973742 0.90 DAO (0.34) DAODDOHSP90AA1ALDH1A1HSD17B10
SCHEMBL3972901 0.87 HSP90AA1 (0.34) DAODDOHSP90AA1ALDH1A1HSD17B10
SCHEMBL1148577 0.81 ALDH1A1 (0.48) DHFRHSP90AA1ALDH1A1HSD17B10KDM4E
SCHEMBL1148678 0.79 HSD17B10 (0.34) HSP90AA1ALDH1A1HSD17B10KDM4ELMNA
SCHEMBL3974853 0.75 ALDH1A1 (0.35) DAODDOHSP90AA1ALDH1A1HSD17B10
SCHEMBL3978017 0.73 HSP90AA1 (0.34) HSP90AA1GAA
SCHEMBL3971825 0.73 HSP90AA1 (0.36) DAODDOHSP90AA1ALDH1A1HSD17B10
SCHEMBL3973855 0.72 GRIN2D (0.34) DAODDOHSP90AA1ALDH1A1HSD17B10
SCHEMBL13280018 0.71 DAO (0.34) DAODDOHSP90AA1ALDH1A1HSD17B10
SCHEMBL1148460 0.71 ALDH1A1 (0.42) HSP90AA1ALDH1A1HSD17B10KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054059-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY Synta Pharmaceuticals Corporation (US) 2009-05-06 EP claimed
WO-2008021364-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2008-02-21 WO claimed
EP-1817295-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY Synta Pharmaceuticals Corporation (US) 2007-08-15 EP claimed
WO-2006055760-A9 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP (US) 2006-09-21 WO claimed
WO-2006055760-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2006-05-26 WO claimed
WO-2008112199-A1 METHOD FOR INHIBITING TOPOISOMERASE II SYNTA PHARMACEUTICALS CORP. (US) 2008-09-18 WO disclosed
WO-2007139952-A2 METHOD FOR THE PREPARATION OF TRIAZOLE COMPOUNDS WITH HSP90 MODULATING ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2007-12-06 WO disclosed