SCHEMBL3972901

SCHEMBL3972901

CCc1cc(-n2nnc(NC(N)=O)c2-c2cccc3[nH]c(C(C)C)cc23)c(O)cc1O

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 13/20 0.34
GRIN2D O15399 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
C5AR1 P21730 1/20 0.32
DAO P14920 1/20 0.31
DDO Q99489 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3974314 0.87 DAO (0.34) HSP90AA1GRIN2DGRIN1GRIN2AGRIN2B
SCHEMBL3973742 0.84 DAO (0.34) HSP90AA1KDM4EALDH1A1LMNAMAPT
SCHEMBL1148622 0.81 P2RX3 (0.33) HSP90AA1C5AR1
SCHEMBL1148341 0.81 LMNA (0.36) LMNA
SCHEMBL1539292 0.75 HSP90AA1 (0.36) HSP90AA1KDM4EALDH1A1LMNAMAPT
SCHEMBL3974853 0.74 ALDH1A1 (0.35) HSP90AA1GRIN2DGRIN1GRIN2AGRIN2B
SCHEMBL2596689 0.70 DAO (0.34) HSP90AA1KDM4EALDH1A1LMNAMAPT
SCHEMBL3973855 0.70 GRIN2D (0.34) HSP90AA1GRIN2DGRIN1GRIN2AGRIN2B
SCHEMBL3978017 0.69 HSP90AA1 (0.34) HSP90AA1
SCHEMBL3971825 0.68 HSP90AA1 (0.36) HSP90AA1KDM4EALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054059-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY Synta Pharmaceuticals Corporation (US) 2009-05-06 EP claimed
WO-2008021364-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2008-02-21 WO claimed
EP-1817295-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY Synta Pharmaceuticals Corporation (US) 2007-08-15 EP claimed
WO-2006055760-A9 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP (US) 2006-09-21 WO claimed
WO-2006055760-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2006-05-26 WO claimed