Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNNC1 | P63316 | 2/20 | 0.38 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972855 | 0.84 | SMN1; SMN2 (0.47) | ALDH1A1HPGDGRIN2DGRIN3BGRIN1 | |
| SCHEMBL8611160 | 0.80 | ALDH1A1 (0.38) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3971781 | 0.78 | ALDH1A1 (0.46) | THRBALDH1A1HPGD | |
| SCHEMBL30081514 | 0.77 | CA1 (0.47) | LMNACA2CA1THRATHRB | |
| SCHEMBL3973752 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDHSD17B10GRIN2DGRIN3B | |
| SCHEMBL27553712 | 0.75 | MAPT (0.34) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL28820658 | 0.74 | NPC1 (0.39) | ALDH1A1 | |
| SCHEMBL3973730 | 0.74 | ADRA2A (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11816669 | 0.73 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27472289 | 0.73 | ALDH1A1 (0.50) | CA2CA1THRATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016061-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | Glaxo Group Limited (GB) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007122241-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |