Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972855 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1KMT2ASMN1; SMN2MAOAHPGD | |
| SCHEMBL3971781 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTKMT2ATSHR | |
| SCHEMBL4096326 | 0.81 | POLB (0.36) | ALDH1A1SMN1; SMN2TSHRNOS1MAPK1 | |
| SCHEMBL11816669 | 0.81 | ALDH1A1 (0.52) | ALDH1A1GAAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3973730 | 0.78 | ADRA2A (0.46) | ALDH1A1GAAMAPTSMN1; SMN2ADRA2A | |
| SCHEMBL3969996 | 0.77 | MLYCD (0.43) | ALDH1A1KMT2AALOX15NOS1CYP3A4 | |
| SCHEMBL4087920 | 0.77 | MEN1 (0.39) | KMT2ANOS1NOS3 | |
| SCHEMBL3974959 | 0.77 | LMNA (0.43) | ALDH1A1SMN1; SMN2HSD17B10HPGDGRIN2D | |
| SCHEMBL3968468 | 0.74 | MAPK1 (0.40) | ALDH1A1GAAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3974584 | 0.74 | MAPT (0.41) | ALDH1A1GAAMAPTSMN1; SMN2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016061-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | Glaxo Group Limited (GB) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007122241-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |