Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974959 | 0.84 | LMNA (0.43) | SMN1; SMN2ALDH1A1HPGDGRIN2DGRIN3B | |
| SCHEMBL3971781 | 0.83 | ALDH1A1 (0.46) | KMT2AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL3973752 | 0.82 | ALDH1A1 (0.46) | SMN1; SMN2MAOAKMT2AALDH1A1HPGD | |
| SCHEMBL3973730 | 0.79 | ADRA2A (0.46) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4096326 | 0.79 | POLB (0.36) | SMN1; SMN2PLAUIDO1ALDH1A1KDM4E | |
| SCHEMBL11816669 | 0.78 | ALDH1A1 (0.52) | SMN1; SMN2KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL3979125 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2PLAUMAOAIDO1KMT2A | |
| SCHEMBL8611160 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1KDM4EPAX8HDAC1 | |
| SCHEMBL4087920 | 0.75 | MEN1 (0.39) | IDO1KMT2AMEN1MLYCD | |
| SCHEMBL3969996 | 0.75 | MLYCD (0.43) | PLAUIDO1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016061-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | Glaxo Group Limited (GB) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007122241-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |