Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL27728905 | 0.98 | GPR84 (0.61) | FFAR1FFAR4GPR84LMNACAMK2A | |
| Adipic Acid SCHEMBL10919803 | 0.95 | FFAR1 (0.65) | FFAR1FFAR4GPR84LMNACAMK2A | |
| Octanedioate SCHEMBL27611818 | 0.95 | GPR84 (0.58) | FFAR1FFAR4GPR84LMNACAMK2A | |
| Adipic Acid SCHEMBL270756 | 0.95 | LMNA (0.61) | FFAR1FFAR4GPR84LMNACAMK2A | |
| Adipic Acid SCHEMBL28688445 | 0.95 | LMNA (0.61) | FFAR1FFAR4GPR84LMNACAMK2A | |
| Sebacic Acid SCHEMBL31652315 | 0.92 | TSHR (0.63) | FFAR1FFAR4GPR84LMNANFKB1 | |
| Glycerin SCHEMBL29687651 | 0.92 | TSHR (0.63) | FFAR1FFAR4GPR84LMNANFKB1 | |
| Pimelic Acid SCHEMBL29894654 | 0.92 | TSHR (0.63) | FFAR1FFAR4GPR84LMNANFKB1 | |
| Azelaic Acid SCHEMBL31615119 | 0.92 | TSHR (0.63) | FFAR1FFAR4GPR84LMNANFKB1 | |
| Sebacic Acid SCHEMBL30008072 | 0.92 | TSHR (0.63) | FFAR1FFAR4GPR84LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104695-A2 | ADHESIVE-FORMING COMPOSITION AND BLEND OF ADHESIVES OBTAINED THEREFROM | Momentive Performance Materials Inc. (US) | 2009-09-30 | — | — | EP | disclosed |
| EP-2057203-A2 | SILYLATED POLYURETHANE COMPOSITIONS AND ADHESIVES THEREFROM | Momentive Performance Materials Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008060506-A2 | ADHESIVE-FORMING COMPOSITION AND BLEND OF ADHESIVES OBTAINED THEREFROM | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008027496-A2 | SILYLATED POLYURETHANE COMPOSITIONS AND ADHESIVES THEREFROM | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2008-03-06 | — | — | WO | disclosed |