Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 12/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975348 | 0.92 | DRD2 (0.46) | DRD2ADRA1ADRD3HTR1AHTR7 | |
| SCHEMBL3975351 | 0.87 | DRD2 (0.61) | DRD2ADRA1ADRD3HTR1AHTR7 | |
| SCHEMBL3197315 | 0.81 | HTR1A (0.66) | DRD2ADRA1ADRD3HTR1AHTR7 | |
| SCHEMBL3982337 | 0.80 | KCNH2 (0.53) | DRD2HTR1AHTR7KCNH2SIGMAR1 | |
| SCHEMBL3978487 | 0.79 | DRD3 (0.64) | DRD2ADRA1ADRD3HTR1AHTR7 | |
| SCHEMBL3982931 | 0.78 | HTR1A (0.47) | DRD2ADRA1ADRD3HTR1AHTR7 | |
| SCHEMBL3973177 | 0.77 | KCNH2 (0.48) | DRD2DRD3HTR1AKCNH2 | |
| SCHEMBL3982377 | 0.77 | HTR7 (0.51) | DRD3HTR1AHTR7 | |
| SCHEMBL3981786 | 0.77 | SIGMAR1 (0.52) | DRD2ADRA1ADRD3HTR1AHTR7 | |
| SCHEMBL3974266 | 0.76 | HTR2A (0.49) | DRD2DRD3HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | claimed |