Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 9/20 | 0.82 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.79 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31513986 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| Hydrochloric Acid SCHEMBL15263292 | 0.99 | ALDH1A1 (0.98) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL14410956 | 0.90 | HTR1A (1.00) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL3454609 | 0.88 | SIGMAR1 (1.00) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL6619322 | 0.84 | ALDH1A1 (0.71) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL10900911 | 0.83 | SIGMAR1 (0.76) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL9519068 | 0.82 | ALDH1A1 (0.69) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL3457736 | 0.81 | SIGMAR1 (0.69) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL11465528 | 0.81 | SIGMAR1 (0.76) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL11560357 | 0.81 | MAPT (0.67) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055001-A2 | METHODS OF TREATING AGING AND METHODS OF SCREENING CANDIDATE AGENTS THEREFOR | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2009-04-30 | — | — | WO | claimed |
| US-20020035998-A1 | Method for treatment of cancer and infectious disease | HELLSTRAND KRISTOFFER (SE) | 2002-03-28 | — | — | US | claimed |
| US-6305380-B1 | ADMINISTERING HISTAMINE AGONIST OR HT3 RECEPTOR ANTAGONIST TO ACTIVATE NATURAL KILLER CELLS AND TREAT VIRAL DISEASES | MAXIM PHARMACEUTICALS, INC. | 2001-10-23 | — | — | US | claimed |
| EP-0652768-B1 | A pharmaceutical preparation for the synergistic activation of natural killer cells | MAXIM PHARM INC (US) | 2000-05-03 | — | — | EP | claimed |
| US-5728378-A | ANTITUMOR AND ANTIVIRUS AGENTS | MAXIM PHARMACEUTICALS, INC. (US) | 1998-03-17 | — | — | US | claimed |
| US-9938525-B2 | Compositions and methods for selective delivery of oligonucleotide molecules to cell types | NLIFE THERAPEUTICS, S.L. (ES) | 2018-04-10 | — | — | US | disclosed |
| CN-103614382-B | Cabbage caterpillar 5-hydroxytryptamine receptor gene Pr5-HT 8and application | ZHEJIANG UNIVERSITY (CN) | 2016-04-13 | — | — | CN | disclosed |
| US-20150315575-A1 | COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO CELL TYPES | PALOMO LIMITED (CY) | 2015-11-05 | — | — | US | disclosed |
| US-20140349969-A1 | COMPOUNDS AND METHODS FOR TREATING PAIN | AKRON MOLECULES AG (AT) | 2014-11-27 | — | — | US | disclosed |
| EP-2674161-A1 | FMO3 inhibitors for treating pain | Akron Molecules GmbH (AT) | 2013-12-18 | — | — | EP | disclosed |
| US-20130252924-A1 | Compounds and Methods for Treating Pain | AKRON MOLECULES GMBH (AT) | 2013-09-26 | — | — | US | disclosed |
| EP-2637649-A2 | COMPOUNDS AND METHODS FOR TREATING PAIN | Akron Molecules GmbH (AT) | 2013-09-18 | — | — | EP | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315575-A1 | COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO CELL TYPES | MSR1, HAVCR2, SNRPE | ALDH1A1 4320/4885CYP1A2 4881/4885CYP3A4 4883/4885 |
| US-20140349969-A1 | COMPOUNDS AND METHODS FOR TREATING PAIN | TRPV1, ACHE, OPRL1 | ALDH1A1 730/4885CYP1A2 2055/4885CYP3A4 2764/4885 |
| US-20130252924-A1 | Compounds and Methods for Treating Pain | TRPV1, ACHE, OPRL1 | ALDH1A1 730/4885CYP1A2 2055/4885CYP3A4 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.