Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971256 | 0.92 | NPC1 (0.47) | MTNR1AMTNR1BNPC1RAB9AMAPK8 | |
| SCHEMBL13883789 | 0.84 | MTNR1A (0.45) | MTNR1AMTNR1BNPC1RAB9AMAPK8 | |
| SCHEMBL3972294 | 0.83 | NAMPT (0.48) | MTNR1AMTNR1BTMEM97SIGMAR1PLA2G4A | |
| SCHEMBL13883856 | 0.82 | MTNR1A (0.53) | MTNR1AMTNR1BPLA2G4AFGFR1 | |
| SCHEMBL3972972 | 0.81 | MTNR1A (0.52) | MTNR1AMTNR1BPLA2G4AFGFR1 | |
| SCHEMBL13883750 | 0.80 | ABCB1 (0.42) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL3976494 | 0.80 | NPC1 (0.52) | MTNR1AMTNR1BNPC1RAB9AMAPK8 | |
| SCHEMBL13884082 | 0.79 | MTNR1A (0.57) | MTNR1AMTNR1BMAPK8PLA2G4AFGFR1 | |
| SCHEMBL3967405 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1BNPC1PLA2G4AFGFR1 | |
| SCHEMBL13883740 | 0.79 | NPC1 (0.48) | MTNR1AMTNR1BNPC1RAB9AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |