Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883789 | 0.92 | MTNR1A (0.45) | NPC1RAB9AMTNR1AMTNR1BEPHX2 | |
| SCHEMBL3976741 | 0.92 | MTNR1A (0.49) | NPC1RAB9AMTNR1AMTNR1BESRRG | |
| SCHEMBL3972294 | 0.91 | NAMPT (0.48) | MTNR1AMTNR1BEPHX2TMEM97SIGMAR1 | |
| SCHEMBL3976494 | 0.88 | NPC1 (0.52) | NPC1RAB9AMTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL3972866 | 0.81 | MTNR1A (0.55) | NPC1RAB9AMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL3971346 | 0.80 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HDAC1LMNA | |
| SCHEMBL3971114 | 0.78 | HIF1A (0.45) | NPC1RAB9AMTNR1AMTNR1BEPHX2 | |
| SCHEMBL13883740 | 0.77 | NPC1 (0.48) | NPC1RAB9AMTNR1AMTNR1BMAPT | |
| SCHEMBL3971172 | 0.76 | PTAFR (0.48) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13883686 | 0.74 | RORC (0.45) | NPC1RAB9AMTNR1AMTNR1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |