Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971256 | 0.91 | NPC1 (0.47) | PLA2G4AMTNR1AMTNR1BHDAC1HDAC2 | |
| SCHEMBL3976494 | 0.87 | NPC1 (0.52) | PLA2G4AMTNR1AMTNR1BHDAC1HDAC2 | |
| SCHEMBL13883789 | 0.83 | MTNR1A (0.45) | PLA2G4AMTNR1AMTNR1BRORCEPHX2 | |
| SCHEMBL3976741 | 0.83 | MTNR1A (0.49) | PLA2G4AMTNR1AMTNR1BHDAC1HDAC2 | |
| SCHEMBL3971346 | 0.81 | NPC1 (0.44) | PLA2G4AHDAC1HDAC2 | |
| SCHEMBL31378117 | 0.78 | TEAD1 (0.55) | PLA2G4ARORC | |
| SCHEMBL3971708 | 0.77 | ABCB1 (0.51) | PLA2G4A | |
| SCHEMBL13883740 | 0.76 | NPC1 (0.48) | PLA2G4AMTNR1AMTNR1BHDAC1HDAC2 | |
| SCHEMBL3971172 | 0.75 | PTAFR (0.48) | HDAC3 | |
| SCHEMBL1356475 | 0.74 | TNF (0.51) | PLA2G4ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |